LeHavreV1, Main, Exploration, bibRecord, 000B34

Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective French Research Axed on Tolerance of Biotherapies registry

Identifieur interne : 000B34 ( Main/Exploration ); précédent : 000B33; suivant : 000B35

Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective French Research Axed on Tolerance of Biotherapies registry

Auteurs : Florence Tubach ; Dominique Salmon ; Philippe Ravaud ; Yannick Allanore ; Philippe Goupille ; Maxime Bréban ; Béatrice Pallot-Prades ; Sophie Pouplin ; Antoinette Sacchi ; Rose Marie Chichemanian ; Stéphane Bretagne ; Dominique Emilie ; Marc Lemann ; Olivier Lorthololary ; Xavier Mariette

Source :

Arthritis and Rheumatism [ 0004-3591 ] ; 2009.

RBID : PMC:2921546

Abstract

Background

Tuberculosis (TB) is associated with anti-tumour necrosis factor (TNF) therapy but whether it is drug-specific remains a concern. Our objective was to describe cases of tuberculosis associated with anti-TNF therapy, identify risk factors and estimate the incidence.

Methods

An incidence study with the French population as reference and a case-control analysis. We collected, for 3 years, cases of TB among French patients receiving anti-TNF therapy, whatever the indication, with two controls treated with anti-TNF agents per case.

Results

We collected 69 cases of TB in patients treated for rheumatoid arthritis (n=40), spondylarthropathies (n=18), inflammatory colitis (n=9), psoriasis (n=1) and Behçet’s disease (n=1) treated with infliximab (n=36), adalimumab (n=28) and etanercept (n=5). None of the cases had received correct chemoprophylaxis treatment. The sex and age-adjusted incidence rate of TB was 116.7 per 100,000 patient-years. The SIR was 12.2 (95% confidence interval 9.7–15.5) and was higher for therapy with infliximab and adalimumab than for that with etanercept: 18.6 (13.4–25.8) and 29.3 (20.2–42.4) versus 1.8 (0.7–4.3), respectively. In the case-control analysis, the exposure to infliximab or adalimumab versus etanercept was an independent risk factor for TB: odds ratio=13.3 (2.6–69.0) and 17.1 (3.6–80.6), respectively. Other risk factors were age, the first year of anti-TNF treatment, and being born in an endemic area.

Conclusions

The risk of TB is higher for patients receiving monoclonal-antibody than soluble-receptor anti-TNF therapy. The increased risk with early anti-TNF treatment and the absence of correct chemoprophylaxis treatment favours the reactivation of latent TB.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921546

DOI: 10.1002/art.24632
PubMed: 19565495
PubMed Central: 2921546

Affiliations:

Le document en format XML

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<author><name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name>
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<addr-line>Faculté de médecine Paris 7 16, Rue Henri Huchard 75018 Paris,FR</addr-line>
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<author><name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name>
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<institution>Hôpital Cochin</institution>
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<author><name sortKey="Allanore, Yannick" sort="Allanore, Yannick" uniqKey="Allanore Y" first="Yannick" last="Allanore">Yannick Allanore</name>
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<author><name sortKey="Goupille, Philippe" sort="Goupille, Philippe" uniqKey="Goupille P" first="Philippe" last="Goupille">Philippe Goupille</name>
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<institution>Université François Rabelais - Tours</institution>
<addr-line>Tours,FR</addr-line>
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<author><name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Bréban">Maxime Bréban</name>
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<author><name sortKey="Pallot Prades, Beatrice" sort="Pallot Prades, Beatrice" uniqKey="Pallot Prades B" first="Béatrice" last="Pallot-Prades">Béatrice Pallot-Prades</name>
<affiliation><nlm:aff id="A7">Service de rhumatologie<institution>Hôpital Bellevue</institution>
<addr-line>Saint-Etienne,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
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<author><name sortKey="Pouplin, Sophie" sort="Pouplin, Sophie" uniqKey="Pouplin S" first="Sophie" last="Pouplin">Sophie Pouplin</name>
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<author><name sortKey="Sacchi, Antoinette" sort="Sacchi, Antoinette" uniqKey="Sacchi A" first="Antoinette" last="Sacchi">Antoinette Sacchi</name>
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<author><name sortKey="Chichemanian, Rose Marie" sort="Chichemanian, Rose Marie" uniqKey="Chichemanian R" first="Rose Marie" last="Chichemanian">Rose Marie Chichemanian</name>
<affiliation><nlm:aff id="A10">Centre régional de pharmacovigilance<institution>Centre régional de pharmacovigilance</institution>
<addr-line>Nice,FR</addr-line>
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<author><name sortKey="Bretagne, Stephane" sort="Bretagne, Stephane" uniqKey="Bretagne S" first="Stéphane" last="Bretagne">Stéphane Bretagne</name>
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<institution>Hôpital Henri Mondor</institution>
<institution>Université Paris-Est</institution>
<addr-line>Créteil,FR</addr-line>
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<author><name sortKey="Emilie, Dominique" sort="Emilie, Dominique" uniqKey="Emilie D" first="Dominique" last="Emilie">Dominique Emilie</name>
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<institution>Hôpital Saint-Louis</institution>
<institution>Université Paris-Diderot - Paris VII</institution>
<addr-line>1 avenue Claude Vellefaux 75475 Paris,FR</addr-line>
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<author><name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lemann">Marc Lemann</name>
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<author><name sortKey="Lorthololary, Olivier" sort="Lorthololary, Olivier" uniqKey="Lorthololary O" first="Olivier" last="Lorthololary">Olivier Lorthololary</name>
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<institution>Hôpital Necker - Enfants Malades</institution>
<institution>Centre d'infectiologie Necker-Pasteur</institution>
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<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
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<institution>IFR93</institution>
<institution>Université Paris Sud - Paris XI</institution>
<addr-line>Faculte de Medecine Paris Sud 63, Rue Gabriel Peri 94276 LE KREMLIN BICETRE CEDEX,FR</addr-line>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective French Research Axed on Tolerance of Biotherapies registry</title>
<author><name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name>
<affiliation><nlm:aff id="A2">Département d'épidémiologie, biostatistique et recherche clinique<institution>AP-HP</institution>
<institution>Hôpital Bichat - Claude Bernard</institution>
<addr-line>46 rue Henri Huchard 75018 Paris,FR</addr-line>
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<wicri:noCountry code="subfield">R</wicri:noCountry>
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<institution>Université Paris-Diderot - Paris VII</institution>
<addr-line>Faculté de médecine Paris 7 16, Rue Henri Huchard 75018 Paris,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
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<author><name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name>
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<institution>Hôpital Cochin</institution>
<institution>Université Paris Descartes</institution>
<addr-line>27 rue du Faubourg Saint Antoine, 75679 Paris Cedex 14, France,FR</addr-line>
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<author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name>
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<institution>Université Paris-Diderot - Paris VII</institution>
<addr-line>Faculté de médecine Paris 7 16, Rue Henri Huchard 75018 Paris,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Département d'épidémiologie, biostatistique et recherche clinique<institution>AP-HP</institution>
<institution>Hôpital Bichat - Claude Bernard</institution>
<addr-line>46 rue Henri Huchard 75018 Paris,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Allanore, Yannick" sort="Allanore, Yannick" uniqKey="Allanore Y" first="Yannick" last="Allanore">Yannick Allanore</name>
<affiliation><nlm:aff id="A4">Service de rhumatologie<institution>AP-HP</institution>
<institution>Hôpital Cochin</institution>
<institution>Université Paris Descartes</institution>
<addr-line>27 rue du Faubourg Saint-Jacques 75679 Paris Cedex 14,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Goupille, Philippe" sort="Goupille, Philippe" uniqKey="Goupille P" first="Philippe" last="Goupille">Philippe Goupille</name>
<affiliation><nlm:aff id="A5">Service de rhumatologie<institution>CHU Tours</institution>
<institution>Université François Rabelais - Tours</institution>
<addr-line>Tours,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Bréban">Maxime Bréban</name>
<affiliation><nlm:aff id="A6">Service de Rhumatologie<institution>AP-HP</institution>
<institution>Hôpital Ambroise Paré</institution>
<addr-line>9 avenue Charles-de-Gaulle 92100 Boulogne,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pallot Prades, Beatrice" sort="Pallot Prades, Beatrice" uniqKey="Pallot Prades B" first="Béatrice" last="Pallot-Prades">Béatrice Pallot-Prades</name>
<affiliation><nlm:aff id="A7">Service de rhumatologie<institution>Hôpital Bellevue</institution>
<addr-line>Saint-Etienne,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pouplin, Sophie" sort="Pouplin, Sophie" uniqKey="Pouplin S" first="Sophie" last="Pouplin">Sophie Pouplin</name>
<affiliation><nlm:aff id="A8">Service de rhumatologie<institution>CHU Rouen</institution>
<addr-line>76000 Rouen,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sacchi, Antoinette" sort="Sacchi, Antoinette" uniqKey="Sacchi A" first="Antoinette" last="Sacchi">Antoinette Sacchi</name>
<affiliation><nlm:aff id="A9">CH F. Quesnay, Service de médecine interne<institution>Centre hospitalier F. Quesnay</institution>
<addr-line>Mantes la Jolie,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chichemanian, Rose Marie" sort="Chichemanian, Rose Marie" uniqKey="Chichemanian R" first="Rose Marie" last="Chichemanian">Rose Marie Chichemanian</name>
<affiliation><nlm:aff id="A10">Centre régional de pharmacovigilance<institution>Centre régional de pharmacovigilance</institution>
<addr-line>Nice,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bretagne, Stephane" sort="Bretagne, Stephane" uniqKey="Bretagne S" first="Stéphane" last="Bretagne">Stéphane Bretagne</name>
<affiliation><nlm:aff id="A11">Service de parasitologie<institution>AP-HP</institution>
<institution>Hôpital Henri Mondor</institution>
<institution>Université Paris-Est</institution>
<addr-line>Créteil,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Emilie, Dominique" sort="Emilie, Dominique" uniqKey="Emilie D" first="Dominique" last="Emilie">Dominique Emilie</name>
<affiliation><nlm:aff id="A12">Service d'hépato-gastro-entérologie<institution>AP-HP</institution>
<institution>Hôpital Saint-Louis</institution>
<institution>Université Paris-Diderot - Paris VII</institution>
<addr-line>1 avenue Claude Vellefaux 75475 Paris,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lemann">Marc Lemann</name>
<affiliation><nlm:aff id="A13">Cytokines, chimiokines et immunopathologie<institution>INSERM : U764</institution>
<institution>IFR13</institution>
<institution>Université Paris Sud - Paris XI</institution>
<addr-line>Centre de Recherche Inserm 32, Rue Des Carnets 92140 CLAMART,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lorthololary, Olivier" sort="Lorthololary, Olivier" uniqKey="Lorthololary O" first="Olivier" last="Lorthololary">Olivier Lorthololary</name>
<affiliation><nlm:aff id="A14">Service des maladies infectieuses et tropicales<institution>Université Paris Descartes</institution>
<institution>AP-HP</institution>
<institution>Hôpital Necker - Enfants Malades</institution>
<institution>Centre d'infectiologie Necker-Pasteur</institution>
<addr-line>Paris,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<affiliation><nlm:aff id="A15">Immunologie antivirale systémique et cérébrale<institution>INSERM : U802</institution>
<institution>IFR93</institution>
<institution>Université Paris Sud - Paris XI</institution>
<addr-line>Faculte de Medecine Paris Sud 63, Rue Gabriel Peri 94276 LE KREMLIN BICETRE CEDEX,FR</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">R</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Arthritis and Rheumatism</title>
<idno type="ISSN">0004-3591</idno>
<idno type="eISSN">1529-0131</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Tuberculosis (TB) is associated with anti-tumour necrosis factor (TNF) therapy but whether it is drug-specific remains a concern. Our objective was to describe cases of tuberculosis associated with anti-TNF therapy, identify risk factors and estimate the incidence.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">An incidence study with the French population as reference and a case-control analysis. We collected, for 3 years, cases of TB among French patients receiving anti-TNF therapy, whatever the indication, with two controls treated with anti-TNF agents per case.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">We collected 69 cases of TB in patients treated for rheumatoid arthritis (n=40), spondylarthropathies (n=18), inflammatory colitis (n=9), psoriasis (n=1) and Behçet’s disease (n=1) treated with infliximab (n=36), adalimumab (n=28) and etanercept (n=5). None of the cases had received correct chemoprophylaxis treatment. The sex and age-adjusted incidence rate of TB was 116.7 per 100,000 patient-years. The SIR was 12.2 (95% confidence interval 9.7–15.5) and was higher for therapy with infliximab and adalimumab than for that with etanercept: 18.6 (13.4–25.8) and 29.3 (20.2–42.4) versus 1.8 (0.7–4.3), respectively. In the case-control analysis, the exposure to infliximab or adalimumab versus etanercept was an independent risk factor for TB: odds ratio=13.3 (2.6–69.0) and 17.1 (3.6–80.6), respectively. Other risk factors were age, the first year of anti-TNF treatment, and being born in an endemic area.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">The risk of TB is higher for patients receiving monoclonal-antibody than soluble-receptor anti-TNF therapy. The increased risk with early anti-TNF treatment and the absence of correct chemoprophylaxis treatment favours the reactivation of latent TB.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Allanore, Yannick" sort="Allanore, Yannick" uniqKey="Allanore Y" first="Yannick" last="Allanore">Yannick Allanore</name>
<name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Bréban">Maxime Bréban</name>
<name sortKey="Bretagne, Stephane" sort="Bretagne, Stephane" uniqKey="Bretagne S" first="Stéphane" last="Bretagne">Stéphane Bretagne</name>
<name sortKey="Chichemanian, Rose Marie" sort="Chichemanian, Rose Marie" uniqKey="Chichemanian R" first="Rose Marie" last="Chichemanian">Rose Marie Chichemanian</name>
<name sortKey="Emilie, Dominique" sort="Emilie, Dominique" uniqKey="Emilie D" first="Dominique" last="Emilie">Dominique Emilie</name>
<name sortKey="Goupille, Philippe" sort="Goupille, Philippe" uniqKey="Goupille P" first="Philippe" last="Goupille">Philippe Goupille</name>
<name sortKey="Lemann, Marc" sort="Lemann, Marc" uniqKey="Lemann M" first="Marc" last="Lemann">Marc Lemann</name>
<name sortKey="Lorthololary, Olivier" sort="Lorthololary, Olivier" uniqKey="Lorthololary O" first="Olivier" last="Lorthololary">Olivier Lorthololary</name>
<name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<name sortKey="Pallot Prades, Beatrice" sort="Pallot Prades, Beatrice" uniqKey="Pallot Prades B" first="Béatrice" last="Pallot-Prades">Béatrice Pallot-Prades</name>
<name sortKey="Pouplin, Sophie" sort="Pouplin, Sophie" uniqKey="Pouplin S" first="Sophie" last="Pouplin">Sophie Pouplin</name>
<name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name>
<name sortKey="Sacchi, Antoinette" sort="Sacchi, Antoinette" uniqKey="Sacchi A" first="Antoinette" last="Sacchi">Antoinette Sacchi</name>
<name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name>
<name sortKey="Tubach, Florence" sort="Tubach, Florence" uniqKey="Tubach F" first="Florence" last="Tubach">Florence Tubach</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B34 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B34 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/France
   |area=    LeHavreV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:2921546
   |texte=   Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective French Research Axed on Tolerance of Biotherapies registry
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:19565495" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LeHavreV1

This area was generated with Dilib version V0.6.25.
Data generation: Sat Dec 3 14:37:02 2016. Site generation: Tue Mar 5 08:25:07 2024

Serveur d'exploration sur la visibilité du Havre

Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective French Research Axed on Tolerance of Biotherapies registry

Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective French Research Axed on Tolerance of Biotherapies registry

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur la visibilité du Havre
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.